Mel Gibson plays Gene Ryack, a renegade pilot and the main protagonist of the film.
Robert Downey Jr. portrays Billy Covington, a resourceful pilot partnered with Gene Ryack in Air America.
Nancy Travis takes on the role of Corinne Landreaux, a compassionate aid worker who becomes involved with the pilots.
Ken Jenkins appears as Major Donald Lemond, a military figure overseeing operations in the film.
David Marshall Grant plays Rob Diehl, a character involved in the chaotic world of Air America.
Lane Smith portrays Senator Davenport, a politician with an interest in the operations of Air America.
Art LaFleur takes on the role of Jack Neely, a character intertwined in the pilots' missions.
Ned Eisenberg plays Pirelli, a character with connections to the pilots' activities.
Marshall Bell appears as O.V., a part of the supporting cast involved in the chaotic setting of Air America.
David Bowe portrays Saunders, a character whose actions impact the main protagonists in the film.
Burt Kwouk appears as General Lu Soong, a military figure with significance in the storyline.
Tim Thomerson plays Babo, a character with a role in the events that unfold in Air America.
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