Richard Pryor portrays Eddie Lenahan, who pretends to be a doctor named Dr. Kevin Slattery in the hospital, leading to comedic situations.
Rachel Ticotin plays Rachel Atwood, a nurse caught up in the chaos caused by Eddie's deception at the hospital.
Rubén Blades portrays Louis, a character involved in the comedic mishaps that unfold in the hospital.
Maria Cardinale appears as Herself, adding a touch of realism to the hospital setting in Critical Condition.
Joe Mantegna takes on the role of Arthur Chambers, a character who interacts with Eddie Lenahan's amusing antics in the hospital.
Bob Dishy plays Dr. Foster, a staff member at the hospital who gets entangled in the chaos caused by Eddie's impersonation.
Sylvia Miles portrays Nurse Maggie Lesser, a character working in the hospital who faces the consequences of Eddie's actions.
Joe Dallesandro appears as Stucky, a character who contributes to the humorous situations unfolding in Critical Condition.
Bob Saget portrays Dr. Joffe, a hospital staff member who deals with the aftermath of Eddie's deceptive actions.
Jon Polito takes on the role of Kline, adding to the cast of characters affected by Eddie Lenahan's antics in Critical Condition.
Garrett Morris appears as Helicopter Junkie, contributing to the quirky and comedic atmosphere of the hospital scenes in Critical Condition.
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