Jack Lemmon portrays Jake Tremont, a workaholic who tries to reconnect with his family after his wife's passing.
Ted Danson plays John Tremont, Jake's successful son who struggles with his father's distant behavior.
Ethan Hawke appears as Billy, John's troubled brother dealing with personal issues.
Kevin Spacey takes on the role of Mario, a family friend who becomes a source of support for John.
Olympia Dukakis portrays Bette Tremont, Jake's wife and the emotional core of the family.
Kathy Baker appears as Annie, a friend of the Tremont family who offers guidance and support.
Zakes Mokae plays Dr. Chad, a medical professional involved in the Tremont family's life-changing events.
J.T. Walsh portrays Dr. Santana, another doctor who plays a role in the family's emotional journey.
Peter Michael Goetz appears as Dr. Ethridge, a medical colleague of Jake's who provides professional insight.
John Apicella plays Dr. Delibro, a doctor involved in the medical issues faced by the Tremont family.
Richard McGonagle portrays Victor Walton, a character who influences the family's decisions and dynamics.
Art Frankel appears as the DMV Instructor, a minor character who adds a touch of humor to the film.
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