Kevin Kline portrays Joey Boca, a philandering pizza parlor owner who becomes the target of his wife's revenge plot.
Tracey Ullman plays Rosalie Boca, Joey's wife who enlists the help of her mother and a group of misfits to take down her cheating spouse.
Joan Plowright stars as Nadja, Rosalie's supportive and resourceful mother who assists in the outrageous plan to eliminate Joey.
River Phoenix portrays Devo Nod, a young man entangled in the chaotic scheme to punish Joey for his infidelity.
William Hurt appears as Harlan James, a key figure involved in the unconventional plot to bring justice to Joey.
Keanu Reeves takes on the role of Marlon James, the brother of Harlan, who aids in the wild and comedic plan to teach Joey a lesson.
James Gammon plays Lt. Larry Schooner, the detective assigned to investigate the bizarre attempted murder of Joey Boca.
Jack Kehler portrays Sgt. Carlos Wiley, a law enforcement officer caught up in the absurd situation surrounding Joey's demise.
Victoria Jackson appears as Lacey, a quirky member of the group trying to bring Joey to justice in the dark comedy I Love You to Death.
Miriam Margolyes plays Joey's Mother, a character entangled in the chaotic and humorous events triggered by her son's unfaithfulness.
Alisan Porter portrays Carla Boca, one of Joey and Rosalie's children who witness the outrageous events unfolding in their family.
Jonathan Kasdan appears as Dominic Boca, another one of Joey and Rosalie's children caught in the tumultuous aftermath of their parents' tumultuous relationship.
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