Tom Skerritt plays Bruce Gardner, Patricia's husband and uncle of Carol Anne, who becomes concerned about the strange occurrences surrounding his family.
Nancy Allen portrays Patricia Wilson-Gardner, Bruce's wife and stepmother to Carol Anne, who struggles to protect her family from the malevolent forces at play.
Heather O'Rourke reprises her role as Carol Anne Freeling, the young girl who remains at the center of the supernatural events, despite efforts to keep her safe.
Lara Flynn Boyle takes on the role of Donna Gardner, Bruce's daughter, who experiences the terror unfolding around her family in the high-rise apartment building.
Kipley Wentz portrays Scott, a friend of Carol Anne who gets caught up in the paranormal disturbances that threaten their lives.
Zelda Rubinstein plays Tangina Barrons, the psychic medium who aids the family in confronting and understanding the supernatural entity haunting them.
Richard Fire appears as Dr. Seaton, a skeptic who initially dismisses the supernatural claims but eventually gets drawn into the terrifying events.
Nathan Davis brings Reverend Henry Kane to life, the malevolent spirit who seeks to capture Carol Anne's soul and wreak havoc on her family.
Joey Garfield plays Jeff, a young boy who becomes entangled in the supernatural occurrences alongside Carol Anne and her friends.
Heather Holty serves as the Stand-in for Carol Anne Freeling, assisting in filming for the character of Carol Anne during certain scenes.
Maureen Mueller appears as Gallery Woman, a mysterious figure who adds to the eerie atmosphere within the high-rise building where the Gardner family resides.
Paty Lombard portrays Helen, a character caught up in the supernatural events affecting the residents of the high-rise building, including Carol Anne and her family.
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