Romy and Michele's High School Reunion Cast

Mira Sorvino portrays Romy White, one of the two best friends who decide to reinvent themselves before attending their high school reunion.

Lisa Kudrow takes on the role of Michele Weinberger, the other half of the dynamic duo who join Romy in their quest to make a big impression at the reunion.

Janeane Garofalo plays the character Heather Mooney, a cynical friend of Romy and Michele who adds a no-nonsense perspective to their plans.

Alan Cumming portrays Sandy Frink, a successful entrepreneur and former classmate who becomes enamored with Romy.

Julia Campbell takes on the role of Christy Masters, a popular and mean-spirited former classmate who looks down on Romy and Michele.

Mia Cottet plays Cheryl Quick, a former classmate who is part of the popular clique that Romy and Michele hope to impress at the reunion.

Kristin Bauer portrays Kelly Possenger, another former classmate who is part of the popular group that Romy and Michele aim to dazzle.

Elaine Hendrix plays Lisa Luder, a glamorous former classmate who adds to the high school nostalgia at the reunion.

Vincent Ventresca takes on the role of Billy Christianson, a former classmate who has a brief encounter with Romy and Michele at the reunion.

Camryn Manheim plays Toby Walters, another former classmate who Romy and Michele reconnect with at the reunion.

Justin Theroux portrays Cowboy, a mysterious former classmate who crosses paths with Romy and Michele during the reunion weekend.

Jacob Vargas plays the character Ramon, a friendly former classmate who interacts with Romy and Michele at the reunion.