Nick Nolte portrays Jack Cates, a tough and determined police detective who reluctantly partners with Reggie Hammond to track down a dangerous criminal.
Eddie Murphy plays Reggie Hammond, a charming and street-smart convict who is released from prison on a 48-hour furlough to help Jack Cates solve a crime.
Annette O'Toole takes on the role of Elaine, a character caught up in the dangerous game between the cops and the criminals in the film.
Frank McRae portrays Haden, a no-nonsense police lieutenant working alongside Jack Cates in the pursuit of justice.
James Remar brings Albert Ganz to life, a ruthless criminal mastermind whose actions set the events of the film in motion.
David Patrick Kelly plays Luther, a dangerous and unpredictable criminal associate of Albert Ganz's.
Sonny Landham portrays Billy Bear, a menacing and violent enforcer working for the main antagonist of the movie.
Brion James plays Ben Kehoe, a member of Albert Ganz's criminal gang who poses a threat to Jack Cates and Reggie Hammond.
Kerry Sherman takes on the role of Rosalie, a character caught up in the criminal activities that Jack Cates and Reggie Hammond are investigating.
Jonathan Banks portrays Algren, a character involved in the law enforcement side of the unfolding drama in 48 Hrs.
James Keane plays Vanzant, a member of law enforcement who works alongside Jack Cates and his team in the pursuit of the criminals.
Tara King portrays Frizzy, a hotel desk clerk who becomes entangled in the dangerous events that unfold over the course of the movie.
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