Matthew Perry plays Alex Whitman, a New Yorker who falls in love with and marries Isabel Fuentes after a one-night stand in Las Vegas.
Salma Hayek Pinault portrays Isabel Fuentes, a free-spirited Mexican-American photographer who unexpectedly finds herself married to Alex Whitman after a Vegas fling.
Jon Tenney plays Jeff, Isabel's ex-boyfriend, who adds a twist to her romantic life with Alex.
Carlos Gómez portrays Chuy, one of Alex's coworkers who offers advice and support throughout his relationship with Isabel.
Tomas Milian plays Tomas Fuentes, Isabel's disapproving father who struggles to accept her relationship with Alex.
Siobhan Fallon Hogan portrays Lanie, Alex's sister who provides insight and comic relief in his tumultuous love life.
John Bennett Perry plays Richard Whitman, Alex's father who tries to guide him through the challenges of marriage and family.
Stanley DeSantis portrays Judd Marshall, a close friend of Isabel's family who offers his peculiar yet well-meaning wisdom.
Suzanne Snyder plays Cathy Stewart, Alex's former girlfriend who complicates his feelings as he navigates his new relationship with Isabel.
Anne Betancourt portrays Amalia, Isabel's mother who adds her own perspective to the challenges faced by the young couple.
Jill Clayburgh plays Nan Whitman, Alex's mother who provides support and understanding as he learns to adjust to his new life.
Angelina Torres portrays Great Grandma, a beloved family member whose wisdom and presence bring comfort and joy to the Whitman family.
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