Peter Liapis portrays Jonathan, the main character who inherits an old mansion where he unknowingly releases demonic creatures known as Ghoulies.
Lisa Pelikan plays Rebecca, Jonathan's girlfriend who becomes entangled in the supernatural events unleashed by the Ghoulies.
Michael Des Barres takes on the role of Malcolm Graves, a sinister cult leader with dark powers who seeks to control the Ghoulies for his own gain.
Jack Nance portrays Wolfgang, a mysterious warlock who warns Jonathan about the dangers of the Ghoulies lurking within the mansion.
Peter Risch appears as Grizzel, one of the Ghoulies who serves as a minion to the dark forces manipulating events in the film.
Tamara De Treaux portrays Greedigut, a grotesque and ravenous Ghoulie creature that embodies insatiable hunger and greed.
Scott Thomson plays Mike, a friend of Jonathan who gets caught up in the chaos unleashed by the Ghoulies within the cursed mansion.
Ralph Seymour takes on the role of Mark, another friend of Jonathan who experiences the terror of the Ghoulies firsthand.
Mariska Hargitay appears as Donna, a character who becomes a target of the malevolent forces controlling the Ghoulies.
Victoria Catlin portrays Anastasia, a member of the occult circle drawn into the dangerous rituals involving the Ghoulies.
Bobbie Bresee plays Temptress, a seductive and enigmatic figure who lures unsuspecting victims into the clutches of the demonic Ghoulies.
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