Albert Brooks plays David Howard, a successful advertising executive who decides to quit his job and embark on a cross-country adventure with his wife.
Julie Hagerty portrays Linda Howard, David's wife who joins him on the journey to explore life outside of their comfortable, suburban lifestyle.
Michael Greene takes on the role of Paul Dunn, a friend of David who offers him a job opportunity that leads to unexpected consequences.
Garry Marshall appears as the Casino Manager who interacts with the couple during a pivotal scene in the film.
Maggie Roswell plays Patty, a character who crosses paths with David and Linda during their unconventional journey.
Tom Tarpey portrays Brad Tooley, a person the couple encounters during their misadventures across America.
Ernie Brown appears as the Pharmacist in a brief but memorable interaction with the protagonists.
Joey Coleman takes on the role of Skippy, a character that adds a comedic element to the story.
Art Frankel plays the Employment Agent who provides a glimpse into the challenges of job hunting on the road.
Donald Gibb appears as the Ex-Convict in a scene that highlights the unpredictability of their journey.
Sylvia Farrel is the Receptionist who briefly interacts with the characters as they navigate their new lifestyle.
Tina Kincaid portrays the Model, a character that represents the allure of a glamorous and carefree existence.
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