Charlie Hunnam plays Nicholas Nickleby, the compassionate and determined protagonist who fights against injustice to protect his family.
Nathan Lane is Vincent Crummles, the eccentric and flamboyant theater troupe manager who befriends Nicholas.
Jim Broadbent portrays Mr. Wackford Squeers, a cruel and unscrupulous headmaster at the Dotheboys Hall boarding school.
Christopher Plummer takes on the role of Ralph Nickleby, Nicholas's cold-hearted and greedy uncle whose actions are driven by self-interest.
Jamie Bell plays Smike, the ill-treated and physically fragile friend of Nicholas who was abused in the Squeers' school.
Anne Hathaway appears as Madeline Bray, a young woman facing her own hardships who becomes a romantic interest for Nicholas.
Alan Cumming is Mr. Folair, a member of the Crummles theatre company who interacts with Nicholas during his time with the troupe.
Timothy Spall portrays Charles Cheeryble, a kind and generous businessman who helps the Nickleby family in their time of need.
Romola Garai plays Kate Nickleby, the courageous and supportive sister of Nicholas, who also faces challenges from their uncle's machinations.
Andrew Havill takes the role of Mr. Nickleby, father to Nicholas and Kate, whose death precipitates the struggles the family faces.
Stella Gonet portrays Mrs. Nickleby, the well-meaning but somewhat naive mother of Nicholas and Kate.
Hugh Mitchell appears as Boy Nicholas Nickleby, reprising the role of the young Nicholas in scenes that reflect upon the character's past.
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