Chris Rock lends his voice to the character of Osmosis Jones.
Laurence Fishburne voices the character of Thrax.
David Hyde Pierce voices the character of Drix.
Brandy Norwood lends her voice to the character of Leah.
Bill Murray portrays the character of Frank Detorre.
Molly Shannon portrays the character of Mrs. Boyd.
William Shatner lends his voice to the character of Mayor Phlegmming.
Ron Howard provides the voice for the character of Tom Colonic.
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