John Wayne plays Ethan Edwards, a complex and brooding Civil War veteran who embarks on a relentless search to rescue his kidnapped niece.
Jeffrey Hunter portrays Martin Pawley, a young man raised by the Edwards family who joins Ethan on his quest to find Debbie.
Vera Miles plays Laurie Jorgensen, a love interest torn between her feelings for Martin and her responsibilities at the Jorgensen homestead.
Ward Bond stars as Rev. Capt. Samuel Johnston Clayton, the local preacher and respected community leader who aids in the search for Debbie.
Natalie Wood portrays Debbie Edwards, the young girl who is abducted and raises questions about identity and belonging.
John Qualen plays Lars Jorgensen, Laurie's father and a Swedish immigrant grappling with loss and the harsh realities of the frontier.
Olive Carey portrays Mrs. Jorgensen, Lars' wife and a resilient frontier woman who must face the trauma of a family member's abduction.
Henry Brandon plays Chief Cicatriz, also known as Scar, the Native American antagonist whose actions serve as a catalyst for the search.
Ken Curtis portrays Charlie McCorry, a loyal companion of Ethan Edwards who joins the search party to rescue Debbie.
Harry Carey, Jr. plays Brad Jorgensen, a member of the Jorgensen family who joins the search for his niece, adding emotional depth to the group.
Antonio Moreno portrays Emilio Gabriel Fernandez y Figueroa, a Mexican rancher who aids in the pursuit of the kidnapped girl, showcasing diverse alliances.
Hank Worden plays Mose Harper, a quirky and loyal sidekick who provides comic relief and unwavering support during the perilous journey.
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