Tom Hanks plays Scott Turner, a neat freak detective who inherits Hooch, a messy Dogue de Bordeaux, and together they make an unlikely crime-solving duo.
Mare Winningham portrays Emily Carson, a veterinarian and love interest to Scott Turner who helps care for Hooch.
Craig T. Nelson takes on the role of Howard Hyde, the police chief and Scott Turner's boss who assigns him the challenging case.
Scott Paulin is Zack Gregory, the main antagonist in the film who is involved in criminal activities that Turner and Hooch are investigating.
John McIntire plays Amos Reed, a key witness in the case who provides vital information to help solve the crime.
Reginald VelJohnson portrays Det. David Sutton, a fellow detective who works with Scott Turner to crack the case involving Hooch.
Mary McCusker appears as Katie, a local resident who interacts with Scott Turner and Hooch during their investigation.
Linda Eve Miller is Mrs. Pine, a character in the film who has a connection to the crime that Scott Turner and Hooch are trying to solve.
Jules Sylvester plays the Animal Control Man, a role that involves dealing with Hooch and his wild antics as a Dogue de Bordeaux.
Ernie Lively appears as the Motel Clerk, a minor character who interacts briefly with Scott Turner during the investigation.
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