Billy Crystal plays Mitch Robbins, a stressed-out New Yorker who goes on a cattle drive adventure to find himself.
Daniel Stern portrays Phil Berquist, Mitch's friend who joins him on the cattle drive journey for a new outlook on life.
Bruno Kirby takes on the role of Ed Furillo, another friend of Mitch and Phil who embarks on the cattle drive for some excitement.
Patricia Wettig appears as Barbara Robbins, Mitch's wife who encourages him to go on the cattle drive to find his happiness.
Helen Slater plays Bonnie Rayburn, a fellow adventurer on the cattle drive who adds a touch of romance to the journey.
Lindsay Crystal portrays Holly Robbins, Mitch's daughter who has a heartwarming relationship with her father.
Noble Willingham is seen as Clay Stone, the tough trail boss who guides the city slickers through their cattle drive experience.
Jack Palance delivers an iconic performance as Curly Washburn, the grizzled cowboy who teaches valuable life lessons to the city slickers.
Tracey Walter plays Cookie, the quirky cook on the cattle drive who adds humor to the group dynamics.
Josh Mostel appears as Barry Shalowitz, one of the comical characters on the cattle drive who provides laughs along the way.
David Paymer portrays Ira Shalowitz, another humorous character on the cattle drive who adds to the group's interactions.
Bill Henderson plays Ben Jessup, a member of the cattle drive crew who contributes to the comedic moments in the film.
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