Dudley Moore plays Emory Leeson, an advertising executive who creates unconventional truthful advertisements.
Daryl Hannah portrays Kathy Burgess, a colleague of Emory Leeson who finds his honesty refreshing.
Paul Reiser takes on the role of Stephen Bachman, a character in the advertising world impacted by Emory's unconventional approach.
J.T. Walsh plays Drucker, another advertising executive affected by the unorthodox advertisements created by Emory Leeson.
David Paymer portrays George, a character involved in the advertising industry who interacts with the unconventional campaign.
Mercedes Ruehl stars as Dr. Liz Baylor, a character in the film connected to the advertising world.
Paul Bates takes on the role of Robles in Crazy People.
Bill Smitrovich plays Bruce, a character who is part of the advertising executive's world.
Doug Yasuda portrays Hsu, a character involved in the events surrounding the unconventional advertising campaign.
Ben Hammer plays Dr. Koch, a character who plays a role in the comedic storyline of the movie.
Jill Pierce stars as Heavy Daughter in the film Crazy People.
Lloyd Kino portrays Mr. Yamashita, a character who becomes part of the humorous narrative.
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