Sinbad portrays Isaiah Turner, the titular character who is a mischievous cowboy searching for his identity and seeking revenge.
James Coburn plays Cyrus Bloomington, a corrupt and wealthy landowner who clashes with Isaiah Turner.
Burt Reynolds appears as Otter Bob the Mountain Man, a rugged outdoorsman who becomes an ally to Isaiah Turner.
A Martinez takes on the role of Juan Cortina, a mysterious and skilled gunslinger with unknown intentions.
Gregory Hines portrays The Undertaker / Jedediah Turner, a charismatic and enigmatic character tied to Isaiah Turner's past.
Ernie Hudson embodies Nat Love aka Deadwood Dick, a legendary gunslinger and mentor figure to Isaiah Turner.
Mark Pellegrino plays Frank Bonner, a menacing antagonist who crosses paths with Isaiah Turner on his journey.
Vanessa Bell Calloway portrays Abby Holsopple, a strong and independent woman who befriends Isaiah Turner.
Hal Williams appears as Rev. Peel, a wise and compassionate figure who provides guidance to Isaiah Turner.
Obba Babatundé takes on the role of Isom Dart, a mysterious and cunning character with his own agenda.
Reginald T. Dorsey portrays Cowboy Graham, a member of the Love Gang who joins Isaiah Turner on his adventures.
Dawnn Lewis plays Stagecoach Mary, a fierce and skilled member of the Love Gang who aids Isaiah Turner in his quest.
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