Steve Martin plays Dr. Michael Hfuhruhurr, a brain surgeon who falls in love with a female gold-digger.
Kathleen Turner portrays Dolores Benedict, the attractive woman who catches the eye of Dr. Hfuhruhurr.
David Warner takes on the role of Dr. Alfred Necessiter, a scientist who helps Dr. Hfuhruhurr with his groundbreaking work.
Paul Benedict plays the Butler who works for Dr. Hfuhruhurr.
Richard Brestoff portrays Dr. Pasteur, a character involved in Dr. Hfuhruhurr's medical world.
James Cromwell appears as the Realtor in the movie.
George Furth plays the character Timon in The Man with Two Brains.
Peter Hobbs portrays Dr. Brandon, a colleague of Dr. Hfuhruhurr.
Earl Boen takes on the role of Dr. Felix Conrad in the film.
Bernie Hern appears as the Gun Seller in The Man with Two Brains.
Francis X. McCarthy plays the character Olsen in the movie.
William Traylor appears as the Inspector in The Man with Two Brains.
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