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Masters of Sex is an American television drama series that aired on Showtime from 2013 to 2016. The show is based on the biography Masters of Sex: The Life and Times of William Masters and Virginia Johnson, the Couple Who Taught America How to Love by Thomas Maier. The series explores the groundbreaking work of William Masters and Virginia Johnson, who conducted pioneering research on human sexuality in the 1950s and 1960s. It delves into the complexities of their personal lives and the obstacles they faced as they sought to unravel the mysteries of human intimacy.