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Rampage is a science fiction film centered on Davis Okoye, a primatologist who has a deep connection with George, a highly intelligent silverback gorilla he raised from birth. The plot unfolds as a genetic experiment transforms George into a monstrous entity, with his size and aggression increasing exponentially. Concurrently, other animals undergo similar transformations, leading to widespread destruction. Okoye collaborates with a disgraced genetic engineer to find a cure, aiming to prevent a global disaster and rescue his once-gentle friend.