James Stewart plays the role of L.B. 'Jeff' Jefferies, a wheelchair-bound photographer who becomes an amateur sleuth while confined to his apartment.
Grace Kelly portrays Lisa Fremont, a fashionable socialite and the girlfriend of Jeff, who joins him in his investigation.
Wendell Corey appears as Det. Lt. Thomas J. Doyle, a police detective who initially doubts Jeff's suspicions but later becomes involved in the case.
Thelma Ritter plays Stella, Jeff's pragmatic and outspoken home care nurse who assists him in piecing together the mystery.
Raymond Burr portrays Lars Thorwald, the enigmatic neighbor across from Jeff's apartment whom Jeff suspects of murder.
Judith Evelyn is Miss Lonelyhearts, a lonely and fragile woman living in the same apartment complex as Jeff, whose story unfolds throughout the film.
Ross Bagdasarian appears as the Songwriter, a composer living in the apartment building whose music provides a backdrop to the events.
Georgine Darcy portrays Miss Torso, a vivacious and flirtatious ballet dancer living across from Jeff, whose romantic escapades entertain him.
Sara Berner is the Woman on Fire Escape, a resident in the neighboring building who becomes inadvertently involved in the unfolding drama.
Frank Cady plays the Man on Fire Escape, another resident in the adjacent building who witnesses suspicious activities, adding to the intrigue.
Jesslyn Fax is Miss Hearing Aid, an elderly neighbor whose keen sense of observation aids Jeff in his quest to uncover the truth.
Rand Harper appears as the Newlywed, a newly married man living nearby, whose mundane yet significant interactions provide moments of levity in the film.
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