Jake Gyllenhaal plays the lead role of Billy 'The Great' Hope, a talented but troubled boxer dealing with personal loss and redemption.
Rachel McAdams portrays Maureen Hope, the supportive wife of Billy Hope who plays a crucial role in his life.
Forest Whitaker takes on the character of Titus 'Tick' Wills, a veteran boxing trainer who helps guide Billy on his path to redemption.
Oona Laurence plays Leila Hope, the young daughter of Billy and Maureen who becomes a driving force in his life.
50 Cent portrays Jordan Mains, a boxer-turned-promoter who plays a significant role in Billy's career.
Skylan Brooks brings Hoppy to life, a supportive friend of Billy who helps him navigate his challenges.
Naomie Harris plays Angela Rivera, a social worker who provides guidance and support to Billy and his family.
Victor Ortiz takes on the role of Ramone, a fellow boxer who crosses paths with Billy during his journey.
Beau Knapp portrays Jon Jon, a pivotal character in Billy's life with connections to his past and present.
Miguel Gómez plays Miguel 'Magic' Escobar, a talented boxer who becomes both a friend and a rival to Billy.
Dominic Colón takes on the character of Mikey, a key figure in Billy's boxing journey.
Jose Caraballo portrays Eli Frost, another boxer in the world of Southpaw who impacts Billy's career.
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