Lucille Ball portrays the quirky and extravagant Mame Dennis, an eccentric woman who embraces life to the fullest.
Bea Arthur plays Vera Charles, Mame's close friend and a witty, sharp-tongued character who adds humor to the story.
Robert Preston takes on the role of Beauregard Jackson Pickett Burnside, a wealthy southern gentleman who captures Mame's heart.
Bruce Davison portrays Patrick as an adult, Mame's grown-up nephew who learns important life lessons from his unconventional aunt.
Kirby Furlong plays Patrick as a boy, capturing the innocence and charm of Mame's young nephew.
Jane Connell takes on the role of Agnes Gooch, Mame's hilariously awkward and endearing personal secretary.
George Chiang portrays Ito, Mame's loyal and dedicated butler who adds a touch of grace to her extravagant lifestyle.
Joyce Van Patten plays Sally Cato, a lively socialite who brings energy and vivacity to the film.
Doria Cook-Nelson embodies Gloria Upson, a snobbish and pretentious character who clashes with Mame's unconventional ways.
Don Porter portrays Mr. Upson, Gloria's father, whose traditional values often conflict with Mame's free-spirited nature.
Audrey Christie plays Mrs. Upson, Gloria's mother, who tries to maintain appearances in the face of Mame's unconventional behavior.
John McGiver takes on the role of Mr. Babcock, Mame's uptight financial advisor who disapproves of her unconventional lifestyle.
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