Phillip Glasser voices the character of Fievel Mousekewitz, the young and adventurous protagonist of the film.
Erica Yohn lends her voice to Mama Mousekewitz, the caring and protective matriarch of the Mousekewitz family.
Nehemiah Persoff provides the voice for Papa Mousekewitz, the hardworking and loving father of Fievel.
Amy Green voices Tanya Mousekewitz, Fievel's older sister who looks out for him during their journey to America.
Christopher Plummer plays Henri, a kind and wise pigeon who befriends Fievel on his adventures.
John Finnegan voices Warren T. Rat, the deceptive and villainous leader of the Mott Street Maulers.
Will Ryan voices Digit, a quirky and loyal sidekick to Warren T. Rat who has a change of heart.
Hal Smith voices Moe, a friendly and helpful mouse who assists Fievel in his quest to find his family.
Pat Musick voices Tony Toponi, a street-smart and resourceful mouse who becomes Fievel's friend.
Cathianne Blore voices Bridget, an Irish mouse who helps Fievel navigate the bustling streets of New York.
Neil Ross voices Honest John, a charismatic con artist in cahoots with Warren T. Rat.
Madeline Kahn voices Gussie Mausheimer, a wealthy socialite mouse who aids the Mousekewitz family in their time of need.
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