Kim Basinger plays Holli Would, a seductive animated character who desires to become a real human in the live-action world.
Gabriel Byrne portrays Jack Deebs, the cartoonist who created the 'Cool World' comic, and later finds himself entangled in the surreal world of his own creation.
Brad Pitt takes on the role of Detective Frank Harris, a police officer who becomes involved in the events unfolding in both the animated and live-action realms.
Michele Abrams plays Jennifer Malley, a human character caught between the two contrasting worlds within the movie.
Deirdre O'Connell portrays Isabelle Malley, another human character within the film who is connected to the unfolding storyline.
Janni Brenn appears as Agatha Rose Harris, a character whose actions impact the narrative of the movie.
William Frankfather takes on the role of one of the cops in the film, contributing to the law enforcement aspect of the story.
Greg Collins portrays another cop character in the film, adding to the police presence in the 'Cool World' universe.
Maurice LaMarche lends his voice to several characters including Interrogator #2, Mash, and the superhero version of Jack Deebs within the animated segments of the movie.
Michael David Lally provides the voice for Sparks, a crucial animated character within the 'Cool World' comic realm.
Carrie Hamilton appears as the Comic Bookstore Cashier, a minor character who contributes to the setting of the story.
Stephen Worth serves as the performance model for Bash and also appears as a Comic Store Patron, adding depth to the animated world.
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