Catalina Sandino Moreno portrays María Álvarez, a young Colombian woman who becomes a drug mule.
Guilied Lopez plays Lucy Díaz, María's friend who also becomes involved in drug trafficking.
Yenny Paola Vega takes on the role of Blanca, another drug mule in the group.
Jhon Álex Toro portrays Franklin, a member of the drug trafficking organization.
Virgina Ariza plays Juana, a fellow drug mule who works alongside María.
Rodrigo Sánchez Borhorquez portrays the Supervisor who oversees the drug mules' activities.
Charles Albert Patiño plays Felipe, a character involved in the drug trafficking operation.
Wilson Guerrero takes on the role of Juan, one of the individuals involved in the drug trade.
Johanna Andrea Mora portrays Diana Álvarez, María's sister.
Evangelina Morales plays Rosita, another character in the drug trafficking network.
Jaime Osorio Gómez portrays Javier, a character connected to the drug trade.
Victor Macias plays the Pellet Maker, a key figure in the drug trafficking operation.
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