My Sister's Keeper Cast
The cast of My Sister's Keeper including popularity data. Data for April 21, 2025.
Cameron Diaz
as Sara Fitzgerald

Portrayed Sara Fitzgerald.

#2
Most popular actor on My Sister's Keeper
8,146 Wikipedia views yesterday
Abigail Breslin
as Andromeda "Anna" Fitzgerald

Played Andromeda 'Anna' Fitzgerald.

#3
Most popular actor on My Sister's Keeper
4,036 Wikipedia views yesterday
Sofia Vassilieva
as Kate Fitzgerald

Portrayed Kate Fitzgerald.

#8
Most popular actor on My Sister's Keeper
457 Wikipedia views yesterday
Alec Baldwin
as Campbell Alexander

Played the role of Campbell Alexander.

#1
Most popular actor on My Sister's Keeper
8,871 Wikipedia views yesterday
Jason Patric
as Brian Fitzgerald

Portrayed Brian Fitzgerald.

#6
Most popular actor on My Sister's Keeper
3,014 Wikipedia views yesterday
Joan Cusack
as Judge De Salvo

Played Judge De Salvo.

#5
Most popular actor on My Sister's Keeper
3,027 Wikipedia views yesterday
Emily Deschanel
as Dr. Farquad

Portrayed Dr. Farquad.

#4
Most popular actor on My Sister's Keeper
3,112 Wikipedia views yesterday
Heather Wahlquist
as Aunt Kelly

Played the role of Aunt Kelly.

Evan Ellingson
as Jesse Fitzgerald
#9
Most popular actor on My Sister's Keeper
346 Wikipedia views yesterday
Frank Cassavetes
as Gus
Nicole Marie Lenz
as Gloria
#10
Most popular actor on My Sister's Keeper
25 Wikipedia views yesterday
Chris Kinkade
as Dr. Nguyen
Rick Salomon
as Bailiff Bert
Frank Peluso
as Bailiff #2
Rico Simonini
as Process Server
Keith Kraft
as Paramedic (uncredited)
Elizabeth Daily
as Nurse Susan
Lin Shaye
as Nurse Adele
#7
Most popular actor on My Sister's Keeper
1,048 Wikipedia views yesterday
Thomas Dekker
as Taylor Ambrose
Jeffrey Markle
as Dr. Wayne
David Thornton
as Dr. Chance
For the best insights and data about My Sister's Keeper, visit our main My Sister's Keeper page.