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My Sister's Keeper
Cast
36 cast members · 20 with popularity data
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Sorted by Buzz Score · May 14, 2026
1
Cameron Diaz
Sara Fitzgerald
6.2
#455 overall
2
Alec Baldwin
Campbell Alexander
4.7
#746 overall
3
Emily Deschanel
Dr. Farquad
2.7
#1,831 overall
4
Joan Cusack
Judge De Salvo
2.0
#2,817 overall
5
Abigail Breslin
Andromeda "Anna" Fitzgerald
1.9
#2,988 overall
6
Jason Patric
Brian Fitzgerald
1.6
#3,605 overall
7
Rick Salomon
Bailiff Bert
1.5
#3,857 overall
8
Lin Shaye
Nurse Adele
0.9
#6,349 overall
9
E. G. Daily
Nurse Susan
0.9
#6,388 overall
10
David Thornton
Dr. Chance
0.8
#7,662 overall
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11
Mary Jo Deschanel
Saleswoman
0.5
#10,076 overall
12
Sofia Vassilieva
Kate Fitzgerald
0.3
#14,670 overall
13
Thomas Dekker
Taylor Ambrose
0.3
#16,217 overall
14
Michael Chow
Dr. Chow
0.3
#16,850 overall
15
Marcos A. Ferraez
EMT
0.2
#19,349 overall
16
Evan Ellingson
Jesse Fitzgerald
0.2
#20,245 overall
17
Heather Wahlquist
Aunt Kelly
0.1
#25,191 overall
18
Ellia English
Nurse Alice
0.1
#30,544 overall
19
Nicole Marie Lenz
Gloria
0.0
#49,105 overall
20
Annie Wood
Uncle Tommy's Wife
0.0
#58,353 overall
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21
Frank Cassavetes
Gus
—
22
Chris Kinkade
Dr. Nguyen
—
23
Jeffrey Markle
Dr. Wayne
—
24
Frank Peluso
Bailiff #2
—
25
Rico Simonini
Process Server
—
26
Keith Kraft
Paramedic (uncredited)
—
27
Nina Barry
Miss Swearingen
—
28
Paul Butler
Jesse age 3
—
29
Walter Raney
Pawn Shop Proprietor
—
30
John DeRosa
EMT
—
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31
Noni Tulk-Perna
Ellen
—
32
Matthew Barry
Uncle Tommy
—
33
David Bortolucci
Harry
—
34
Andrew Schaff
Nurse Stephen
—
35
Mimi Fletcher
De Salvo's Secretary
—
36
Kaleti Williams
Bouncer (uncredited)
—
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