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My Sister's Keeper
Cast
36 cast members · 20 with popularity data
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Sorted by Buzz Score · May 21, 2026
1
Cameron Diaz
Sara Fitzgerald
8.3
#240 overall
2
Alec Baldwin
Campbell Alexander
4.7
#694 overall
3
Emily Deschanel
Dr. Farquad
2.5
#1,983 overall
4
Abigail Breslin
Andromeda "Anna" Fitzgerald
2.4
#2,118 overall
5
Joan Cusack
Judge De Salvo
2.2
#2,328 overall
6
Rick Salomon
Bailiff Bert
1.5
#3,703 overall
7
Jason Patric
Brian Fitzgerald
1.3
#4,202 overall
8
E. G. Daily
Nurse Susan
1.2
#4,537 overall
9
Lin Shaye
Nurse Adele
0.7
#7,794 overall
10
David Thornton
Dr. Chance
0.7
#8,258 overall
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11
Mary Jo Deschanel
Saleswoman
0.5
#10,215 overall
12
Thomas Dekker
Taylor Ambrose
0.3
#13,534 overall
13
Sofia Vassilieva
Kate Fitzgerald
0.3
#15,468 overall
14
Marcos A. Ferraez
EMT
0.2
#17,489 overall
15
Michael Chow
Dr. Chow
0.2
#18,689 overall
16
Evan Ellingson
Jesse Fitzgerald
0.2
#20,420 overall
17
Heather Wahlquist
Aunt Kelly
0.1
#23,730 overall
18
Ellia English
Nurse Alice
0.1
#31,578 overall
19
Nicole Marie Lenz
Gloria
0.0
#44,880 overall
20
Annie Wood
Uncle Tommy's Wife
0.0
#53,319 overall
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21
Frank Cassavetes
Gus
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22
Chris Kinkade
Dr. Nguyen
—
23
Jeffrey Markle
Dr. Wayne
—
24
Frank Peluso
Bailiff #2
—
25
Rico Simonini
Process Server
—
26
Keith Kraft
Paramedic (uncredited)
—
27
Nina Barry
Miss Swearingen
—
28
Paul Butler
Jesse age 3
—
29
Walter Raney
Pawn Shop Proprietor
—
30
John DeRosa
EMT
—
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31
Noni Tulk-Perna
Ellen
—
32
Matthew Barry
Uncle Tommy
—
33
David Bortolucci
Harry
—
34
Andrew Schaff
Nurse Stephen
—
35
Mimi Fletcher
De Salvo's Secretary
—
36
Kaleti Williams
Bouncer (uncredited)
—
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