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My Sister's Keeper
Cast
36 cast members · 20 with popularity data
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Sorted by Buzz Score · June 23, 2026
1
Joan Cusack
Judge De Salvo
11.2
#129 overall
2
Cameron Diaz
Sara Fitzgerald
4.9
#602 overall
3
Alec Baldwin
Campbell Alexander
4.6
#686 overall
4
Emily Deschanel
Dr. Farquad
2.2
#2,286 overall
5
Abigail Breslin
Andromeda "Anna" Fitzgerald
2.0
#2,553 overall
6
Lin Shaye
Nurse Adele
1.8
#2,896 overall
7
Jason Patric
Brian Fitzgerald
1.3
#4,346 overall
8
Rick Salomon
Bailiff Bert
1.1
#5,316 overall
9
E. G. Daily
Nurse Susan
0.9
#6,410 overall
10
David Thornton
Dr. Chance
0.8
#7,249 overall
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11
Sofia Vassilieva
Kate Fitzgerald
0.6
#9,486 overall
12
Mary Jo Deschanel
Saleswoman
0.4
#11,315 overall
13
Thomas Dekker
Taylor Ambrose
0.4
#12,982 overall
14
Evan Ellingson
Jesse Fitzgerald
0.3
#16,125 overall
15
Marcos A. Ferraez
EMT
0.2
#18,797 overall
16
Heather Wahlquist
Aunt Kelly
0.1
#22,481 overall
17
Michael Chow
Dr. Chow
0.1
#22,529 overall
18
Ellia English
Nurse Alice
0.1
#25,338 overall
19
Nicole Marie Lenz
Gloria
0.0
#46,896 overall
20
Annie Wood
Uncle Tommy's Wife
0.0
#55,824 overall
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21
Frank Cassavetes
Gus
—
22
Chris Kinkade
Dr. Nguyen
—
23
Jeffrey Markle
Dr. Wayne
—
24
Frank Peluso
Bailiff #2
—
25
Rico Simonini
Process Server
—
26
Keith Kraft
Paramedic (uncredited)
—
27
Nina Barry
Miss Swearingen
—
28
Paul Butler
Jesse age 3
—
29
Walter Raney
Pawn Shop Proprietor
—
30
John DeRosa
EMT
—
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31
Noni Tulk-Perna
Ellen
—
32
Matthew Barry
Uncle Tommy
—
33
David Bortolucci
Harry
—
34
Andrew Schaff
Nurse Stephen
—
35
Mimi Fletcher
De Salvo's Secretary
—
36
Kaleti Williams
Bouncer (uncredited)
—
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