Tommy Lee Jones plays Billy, a mysterious drifter who forms an unlikely bond with a young girl named Jonsy.
Martha Plimpton portrays Jonsy, a young girl who befriends the enigmatic stranger Billy and embarks on an adventure with him.
Brian Dennehy takes on the role of Doc Cole, a wise and grizzled river man who becomes entangled in Billy and Jonsy's journey.
Shawn Smith plays Wexel, a character caught up in the unfolding events alongside Billy and Jonsy.
Nancy Lea Owen is Vadie, a character whose path crosses with Billy, Jonsy, and the others, adding layers to the story.
Norman Bennett portrays Sheriff Cal, a lawman who becomes involved in the events set in motion by Billy's presence in town.
Tony Frank takes on the role of Poley, a character who interacts with the central figures in The River Rat.
Angie Bolling portrays Joyce, a character whose connection to the past plays a role in the unfolding narrative of the film.
Roger Copeland plays Young Billy, providing insight into the backstory of the character portrayed by Tommy Lee Jones.
Tommy Burlison is Whitey, a character who adds depth to the world of The River Rat and interacts with the main cast.
Tamara Hartley portrays Young Joyce, shedding light on a key character's past and its impact on the present.
Louis Plante appears as Cajun Deputy, a character who becomes involved in the events that unfold in the story of The River Rat.
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