The Twisted Tale of Amanda Knox (TV) Cast
The cast of The Twisted Tale of Amanda Knox. Updated on August 28, 2025.
6 actors
Grace Van Patten
as Amanda Knox (8 episodes)

Grace Van Patten portrays Amanda Knox, an American college student who becomes embroiled in a high-profile legal battle in Italy.

Sharon Horgan
as Edda Mellas (8 episodes)

Sharon Horgan plays Edda Mellas, Amanda Knox's supportive mother who navigates the challenges of her daughter's legal troubles.

Giuseppe De Domenico
as Raffaele Sollecito (8 episodes)

Giuseppe De Domenico takes on the role of Raffaele Sollecito, Amanda Knox's boyfriend at the time, who is also implicated in the case.

John Hoogenakker
as Curt Knox (8 episodes)

John Hoogenakker appears as Curt Knox, Amanda Knox's determined father, seeking justice for his daughter.

Roberta Mattei
as Monica Napoleoni (8 episodes)

Roberta Mattei portrays Monica Napoleoni, a key Italian investigator in the murder case.

Francesco Acquaroli
as Giuliano Mignini (8 episodes)

Francesco Acquaroli steps into the role of Giuliano Mignini, the persistent public prosecutor involved in the case.

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