Warren Beatty plays Clyde Barrow, one half of the criminal duo known for their bank heists during the Great Depression.
Faye Dunaway portrays Bonnie Parker, a young woman who partners with Clyde in crime and rebellion.
Michael J. Pollard plays C. W. Moss, a young accomplice who gets involved with Bonnie and Clyde's criminal activities.
Gene Hackman portrays Buck Barrow, Clyde's older brother who joins the couple in their lawless lifestyle.
Estelle Parsons takes on the role of Blanche, Buck's wife, who struggles to cope with the events surrounding the gang.
Denver Pyle plays Frank Hamer, a Texas Ranger determined to bring Bonnie and Clyde to justice.
Dub Taylor portrays Ivan Moss, C.W. Moss's father who becomes entangled in the gang's activities.
Evans Evans plays Velma Davis, a character who interacts with Bonnie and Clyde.
Gene Wilder appears as Eugene Grizzard, a minor character who encounters the main characters.
Mabel Cavitt plays Bonnie's mother, an uncredited role that highlights Bonnie's family background.
Patrick Cranshaw appears as a Bank Teller in an uncredited role during one of the heists.
Owen Bush plays a Policeman in an uncredited role, representing law enforcement's pursuit of the criminals.
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