Jennifer Tilly portrays Tiffany Valentine, the former girlfriend of Chucky who becomes a doll and seeks to transfer her soul into a human body.
Brad Dourif provides the voice for Chucky, the serial killer whose soul inhabits a doll and who is now seeking a female doll to be his bride.
Katherine Heigl plays Jade Kincaid, one half of the young couple who gets caught up in the chaos when Chucky and Tiffany go on a murderous rampage.
Nick Stabile stars as Jesse, Jade's boyfriend who unwittingly revives the dolls Chucky and Tiffany, setting off a chain of deadly events.
Gordon Michael Woolvett portrays David Collins, Jesse's best friend who also becomes entangled in the dolls' murderous plans.
Alexis Arquette appears as Damien Baylock, a goth teenager who plays a key role in helping Chucky and Tiffany carry out their sinister plans.
John Ritter plays Chief Warren Kincaid, Jade's overprotective uncle who becomes embroiled in the chaos caused by the killer dolls.
Lawrence Dane stars as Lt. Preston, a police officer who gets involved in the investigation of the murders committed by Chucky and Tiffany.
Michael Louis Johnson appears as Norton, a worker who unwittingly assists Chucky and Tiffany in their quest for a human body.
James Gallanders plays Russ, a character who becomes a victim of the killer dolls' murderous machinations.
Janet Kidder portrays Diane, a character who gets caught up in the bloody mayhem caused by Chucky and Tiffany.
Vince Corazza appears as Robert Bailey, another unfortunate soul who crosses paths with the deadly dolls in Bride of Chucky.
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