Sidney Poitier plays Buck, a skilled wagon master who teams up with Preacher to protect their wagon train from bounty hunters.
Harry Belafonte portrays the character of Preacher, a con man who joins forces with Buck to safeguard the wagon train from bounty hunters.
Ruby Dee takes on the role of Ruth, a character who is part of the wagon train that Buck and Preacher are protecting.
Cameron Mitchell plays Deshay, a member of the group trying to steal weapons from the wagon train.
Denny Miller portrays Floyd, another member of the group looking to steal weapons from the wagon train.
Nita Talbot plays Madam Esther, a character involved in the events surrounding the wagon train.
John Kelly portrays the Sheriff who is after Buck and Preacher as they protect the wagon train.
Tony Brubaker plays Headman, a character within the wagon train group under threat.
Bobby Johnson portrays the Man Who is Shot during the course of the events in the movie.
James McEachin plays Kingston, a character involved in the challenges faced by the wagon train.
Clarence Muse portrays Cudjo, an individual within the group protected by Buck and Preacher.
Lynn Hamilton plays Sarah, a character within the wagon train under threat and protection.
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