Cast of Drugstore Cowboy

Matt Dillon portrays Bob, the charismatic and adventurous leader of a group of drug addicts who engage in a series of pharmacy robberies.

Kelly Lynch plays Dianne, Bob's loyal and understanding wife who supports him through their turbulent lifestyle.

James Remar takes on the role of Gentry, a member of Bob's close-knit group of drug-using friends.

James Le Gros stars as Rick, another member of Bob's group who joins in on the risky pharmacy heists.

Heather Graham portrays Nadine, a young and impressionable girl who gets caught up in the illicit activities of Bob's crew.

Beah Richards appears as the Drug Counselor who tries to help Bob and his friends break free from their addiction.

Grace Zabriskie plays Bob's Mother, a concerned and loving figure who worries about her son's dangerous lifestyle.

Max Perlich is David, one of the members of Bob's group who becomes entangled in the cycle of drug abuse and crime.

William S. Burroughs appears as Tom the Priest, a mysterious character who crosses paths with Bob and his friends.

Eric Hull takes on the role of the Druggist, a pharmacy employee who becomes a target of Bob's criminal activities.

John Kelly plays a Cop who is hot on the trail of Bob and his friends as they continue their spree of pharmacy robberies.

George Catalano appears as Trousinski, a character involved in the criminal underworld that Bob and his friends navigate.