Tupac Shakur plays Ezekiel 'Spoon' Whitmore, a member of the group of friends trying to navigate the bureaucratic challenges of the healthcare system.
Tim Roth portrays Alexander 'Stretch' Rawland, a friend of Spoon caught in a web of challenges as they attempt to seek help for their friend.
Thandiwe Newton embodies the character of Barbara 'Cookie' Cook, a central figure in the friends' lives facing the consequences of their lifestyle.
Charles Fleischer takes on the role of Mr. Woodson, a character intertwined with the friends' struggles as they try to find solutions to their problems.
Howard Hesseman appears as the Blind Man, a supporting character who adds depth and complexity to the friends' journey through urban challenges.
Vondie Curtis-Hall portrays D-Reper, a character whose presence adds tension and obstacles to the friends' quest for help and understanding.
John Sayles plays Cop #1, a minor character who interacts with the friends, contributing to the intricate web of challenges they face.
Lucy Liu brings Cee-cee to life, adding another layer to the friends' world as they navigate the complexities of the urban environment.
Bokeem Woodbine appears as Mud (uncredited), a character whose actions impact the friends' journey in unexpected ways.
Kasi Lemmons embodies the character of Madonna, adding depth and significance to the friends' interactions and challenges.
Tom Towles portrays D-Reper's Henchman, a character who adds an element of danger and unpredictability to the group's struggles and decisions.
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