Cast of Harry and the Hendersons

John Lithgow plays George Henderson, the head of the Henderson family who takes in Harry and tries to protect him.

Melinda Dillon portrays Nancy Henderson, George's wife, who is initially wary of Harry but grows to care for him.

Margaret Langrick takes on the role of Sarah Henderson, the teenage daughter of the Henderson family.

Joshua Rudoy plays Ernie Henderson, the young son in the Henderson family who forms a close bond with Harry.

Kevin Peter Hall brings Harry to life, portraying the gentle Sasquatch who finds himself welcomed into the Henderson family.

David Suchet appears as Jacques Lafleur, a French-Canadian hunter who is determined to capture Harry.

Lainie Kazan plays Irene Moffitt, a friend of the Henderson family who helps them navigate the challenges of having Harry around.

Don Ameche portrays Dr. Wallace Wrightwood, a scientist who studies Harry and helps the Hendersons understand him better.

M. Emmet Walsh appears as George Henderson Sr., George's father, who struggles to accept Harry's presence in their lives.

Laura Kenny plays 'Mouse' Woman, a local who shares stories about Sasquatches and helps the Henderson family.

William Ontiveros portrays Sgt. Mancini, a police officer who gets involved in the chaos surrounding Harry.

David Richardt appears as a Dirty Harry Officer, one of the law enforcement officers who encounter Harry in the city.