Sean Connery portrays Dr. Robert Campbell, a dedicated scientist searching for a cure for cancer in the Amazon rainforest.
Lorraine Bracco plays Dr. Rae Crane, a researcher who joins Dr. Campbell in his quest to find the cure for cancer.
José Wilker takes on the role of Dr. Miguel Ornega, a native Brazilian who assists Dr. Campbell and Dr. Crane in their medical research.
Rodolfo De Alexandre portrays Tanaki, a member of the indigenous tribe residing in the rainforest where Dr. Campbell conducts his research.
Francisco Tsiren Tsere Rereme plays Jahausa, another member of the indigenous tribe who interacts with Dr. Campbell and his team.
Elias Monteiro Da Silva takes on the role of Palala, a member of the indigenous tribe involved in the medical discoveries of Dr. Campbell.
Edinei Maria Serrio Dos Santos portrays Kalana, a member of the indigenous tribe living in the Amazon rainforest where the medical breakthrough takes place.
Bec-Kana-Re Dos Santos Kaiapo plays Imana, a member of the indigenous tribe who plays a significant role in the events unfolding in the rainforest.
Angelo Barra Moreira portrays Medicine Man, a mysterious figure in the rainforest who crosses paths with Dr. Campbell on his quest for a cancer cure.
José Lavat plays Government Man, a character involved in the bureaucratic and regulatory aspects of Dr. Campbell's medical research in the Amazon.
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