Annabeth Gish stars as Kat Arujo, a responsible and level-headed waitress who dreams of going to Yale.
Julia Roberts plays Daisy Arujo, Kat's more rebellious and adventurous sister who starts to question her lifestyle choices.
Lili Taylor portrays Jojo, the outspoken and free-spirited third waitress at Mystic Pizza.
Vincent D'Onofrio appears as Bill, a wealthy guy who falls for Kat and challenges her views on love and relationships.
William R. Moses plays Tim Travers, Daisy's wealthy boyfriend who struggles to understand her need for independence.
Adam Storke portrays Charles Gordon Windsor, Jr., a charming local who catches Daisy's eye.
Matt Damon has a small role as Steamer, one of the guys in town who flirts with the waitresses.
Conchata Ferrell appears as Leona, the no-nonsense owner of Mystic Pizza who watches over the young waitresses like a mother figure.
Joanna Merlin plays Mrs. Arujo, Kat and Daisy's mother who has high expectations for her daughters' futures.
Porscha Radcliffe portrays Phoebe, a friend of the waitresses who provide comic relief in the movie.
John Fiore appears as Jake, a local fisherman who has a connection to one of the waitresses.
Gene Amoroso plays Mr. Barboza, a minor character in the movie who interacts with the main cast.
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