Uma Thurman plays Noelle, a glamorous and confident model who helps out her shy and insecure radio host friend in a unique way.
Janeane Garofalo portrays Dr. Abby Barnes, the witty and intelligent radio host who struggles with self-esteem and enlists the help of her attractive neighbor.
Ben Chaplin takes on the role of Brian, a romantic and charming photographer who becomes enamored with the fake persona of Noelle.
Jamie Foxx plays Ed, a friend of Abby's who provides comedic relief and moral support throughout the film.
James McCaffrey portrays Roy, a flirtatious acquaintance of Abby who complicates the romantic entanglements in the story.
Richard Coca plays Eric, a supportive friend of Abby who offers advice and encouragement when needed.
Stanley DeSantis takes on the role of Mario, adding a quirky and comedic element to the mix as he interacts with the main characters.
Antoinette Valente portrays Susan, a friend of Abby's who provides a different perspective on relationships and self-image.
Mitch Rouse plays Bee Man, a character who adds a humorous and unconventional element to the story.
La Tanya M. Fisher portrays Emily, a supportive friend who offers a listening ear and words of wisdom to Abby.
Faryn Einhorn plays the Child Model, adding a touch of innocence and youthful energy to the scenes.
David Cross voices the Male Radio Caller and also portrays the Bookstore Man, adding depth to the radio show and bookstore scenes.
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