One Mississippi

Tig Notaro portrays the main character, Tig, in One Mississippi. Tig is a comedian who returns to her hometown in Mississippi to confront her past and reconnect with her family after the death of her mother.

Rya Kihlstedt plays the role of Caroline in One Mississippi. Caroline is Tig's stepfather's girlfriend, who becomes a part of Tig's extended family as they navigate through their grief and changes in their lives.

John Rothman portrays the character of Bill in One Mississippi. Bill is Tig's stepfather, who is trying to cope with the loss of his wife while also trying to support and understand Tig during her return to their hometown.

Noah Harpster plays the role of Remy in One Mississippi. Remy is Tig's older brother, who has his own struggles and demons to face while dealing with their mother's death and the challenges of their family dynamics.

Stephanie Allynne portrays Kate in One Mississippi. Kate is Tig's girlfriend, who supports her throughout her journey back to Mississippi and helps her navigate through the emotional and personal challenges.

Casey Wilson plays the role of Brooke in One Mississippi. Brooke is Tig's childhood friend who offers her support and humor as they reminisce about their past and deal with the present.

Sheryl Lee Ralph portrays Felicia in One Mississippi. Felicia is Tig's radio show co-host and friend, who provides advice and perspective on life while also dealing with her own personal struggles.

Lesley Arfin plays the role of Anja Lott in One Mississippi. Anja is Tig's former girlfriend, who reappears in her life and causes her to reflect on their past relationship and its impact on her present.