WHAT / IF (TV) Cast
The cast of WHAT / IF. Updated on October 7, 2025.
46 actors
Renée Zellweger
as Anne Montgomery (10 episodes)

Renée Zellweger portrays Anne Montgomery, a wealthy and powerful woman who makes Lisa the life-changing proposition. Zellweger is an American actress who has won several awards, including an Academy Award for her role in the film 'Cold Mountain'.

Jane Levy
as Lisa Ruiz-Donovan (10 episodes)

Jane Levy portrays Lisa Ruiz-Donovan, a talented scientist who is confronted with a life-altering proposal that tests her values and morals. Levy is an American actress known for her roles in television shows such as 'Suburgatory' and 'Castle Rock'.

Blake Jenner
as Sean Donovan (10 episodes)

Blake Jenner plays the character of Sean Donovan, Lisa's husband and a passionate baseball player who dreams of making it big. Jenner is an American actor known for his work in the musical television series 'Glee' and the film 'Everybody Wants Some!!'.

Keith Powers
as Todd Archer (10 episodes)

Keith Powers portrays Todd Archer, a close friend of Lisa and Sean. Todd is ambitious and has a knack for business. Powers is an American actor and model who has appeared in films such as 'Straight Outta Compton' and the television series 'Famous in Love'.

Samantha Marie Ware
as Angela Archer (10 episodes)

Samantha Marie Ware plays Angela Archer, Todd's girlfriend and an aspiring singer. Angela is determined to achieve success in her music career. Ware is an American actress and singer who gained recognition for her role in the musical television series 'Glee'.

Juan Castano
as Marcos Ruiz (10 episodes)

Juan Castano takes on the role of Marcos Ruiz, Lisa's brother and a police officer. Marcos is protective of his sister and is torn between duty and family. Castano is a Colombian-American actor known for his performances in the play 'Transfers' and the television series 'The OA'.

Bonnie Bedelia
as Margaret (1 episode)

Bonnie Bedelia appears as Margaret, Lisa's adoptive mother who has her own secrets and past. Bedelia is an American actress known for her roles in films like 'Die Hard' and 'Heart Like a Wheel'.

Simon Hunt
as Sergeant Miller (1 episode)

Simon Hunt plays Sergeant Miller, a police officer who becomes involved in the unfolding events. Hunt is an actor known for his work in television shows such as 'Killing Eve' and 'Strike Back'.

Ludwig Manukian
as Gabriel (1 episode)
Jessica Sarah Flaum
as Teenage Anne (1 episode)
Jonathan Ohye
as Dr. Rye (1 episode)
Michael Dempsey
as Barry (1 episode)
David Barrera
as Lisa's Father (1 episode)
Martin Kildare
as Clive (1 episode)
Julian Sands
as Liam Strom (2 episodes)
Gabriel Mann
as Gage Scott (2 episodes)
Monique Kim
as Miles (1 episode)
Brenda Bakke
as Older Laura (1 episode)
Harry Zinn
as Judge Randol Sassen (1 episode)
Jan Jeffcoat
as Financial Reporter (1 episode)
Kim Rhodes
as Diane Foy (1 episode)
TJ Linnard
as (1 episode)
Margarita Franco
as Lisa's mother (2 episodes)
Celeste Den
as Dr. June Smith (1 episode)
Nana Ghana
as Sophie (1 episode)
Gus Cooper
as Cuban man (1 episode)
Jay Jackson
as Local anchor (1 episode)
Dave Annable
as Dr. Ian Harris (3 episodes)
Daniella Pineda
as Cassidy (3 episodes)
Josh Kelly
as (2 episodes)
Saamer Usmani
as Avery (3 episodes)
Keegan Allen
as Billy (1 episode)
Bobby Hosea
as Todd's father (1 episode)
Derek Smith
as Kevin (2 episodes)
Allie MacDonald
as Maddie Carter (1 episode)
Kristen Hager
as Laura (2 episodes)
Hunter Doohan
as Tyler (1 episode)
Ashley Fink
as Lori Parker (1 episode)
Marissa Cuevas
as Christine (1 episode)
Brian Tichnell
as Paul (1 episode)
London Vanovan
as Young Anne (1 episode)
Ian Inigo
as Young Marcos (1 episode)
Ben Dukes
as Redneck Guy (1 episode)
Dionne Neish
as Co-pilot (1 episode)
Michael Naizu
as Random Jock (1 episode)
Tyler Ross
as Franklin (1 episode)
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