Burt Lancaster stars as Mel Bakersfeld, the harried airport general manager trying to avert disaster.
Dana Wynter plays Cindy Bakersfeld, Mel's estranged wife caught up in the chaos at the airport.
Dean Martin portrays Vernon Demerest, a charming but troubled pilot facing personal and professional challenges.
Barbara Hale takes on the role of Sarah Demerest, Vernon's loyal and supportive wife.
Jean Seberg is Tanya Livingston, a young and troubled woman with a mysterious past.
Jacqueline Bisset plays Gwen Meighen, the head stewardess on the ill-fated flight.
George Kennedy is Joe Patroni, the skilled and resourceful chief mechanic faced with a high-stakes challenge.
Jodean Lawrence appears as Marie Patroni, Joe's supportive and worried wife.
Helen Hayes portrays Ada Quonsett, a stowaway with a surprising impact on the unfolding events.
John Findlater is Peter Coakley, a young airport employee caught up in the crisis.
Van Heflin plays D. O. Guerrero, a desperate and conflicted man with a dangerous plan.
Maureen Stapleton portrays Inez Guerrero, D. O.'s devoted and troubled wife.
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