William Hurt portrays Professor Eddie Jessup, a scientist who delves into altered states of consciousness through unconventional methods.
Blair Brown plays Emily Jessup, the wife of Professor Jessup who struggles to understand his obsessions and experiments.
Bob Balaban takes on the role of Arthur Rosenberg, a fellow scientist and colleague of Professor Jessup.
Charles Haid portrays Mason Parrish, a friend and advisor to Professor Jessup as he delves deeper into his experiments.
Thaao Penghlis plays Echeverria, a guide who assists Professor Jessup in exploring altered states of consciousness.
Miguel Godreau appears as the Primal Man, a primal figure that Professor Jessup encounters during his experiments.
Dori Brenner portrays Sylvia Rosenberg, the wife of Arthur Rosenberg and a key figure in the story.
Peter Brandon takes on the role of Hobart, a colleague of Professor Jessup who is intrigued by his experiments.
Charles White-Eagle appears as The Brujo, a mystical figure who influences Professor Jessup's journey.
Drew Barrymore plays Margaret Jessup, the daughter of Professor Jessup and Emily Jessup.
Megan Jeffers portrays Grace Jessup, another daughter of Professor Jessup and Emily Jessup.
Jack Murdock plays Hector Orteco, a colleague of Professor Jessup who gets caught up in the consequences of his experiments.
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