Cast of Annihilation

Natalie Portman plays Lena, a biologist and former soldier who joins the expedition into the mysterious Area X to find out what happened to her husband.

Jennifer Jason Leigh portrays Dr. Ventress, the psychologist leading the team into Area X, driven by her own hidden motivations and secrets.

Gina Rodriguez takes on the role of Anya Thorensen, an outspoken paramedic with a troubled past who brings a fierce determination to the mission.

Tessa Thompson plays Josie Radek, a physicist who brings a quiet sensitivity to the team and forms a unique connection with the mysterious landscape of Area X.

Tuva Novotny portrays Cass Sheppard, a geologist whose pragmatic approach to problem-solving is tested in the surreal and dangerous environment of Area X.

Oscar Isaac plays Kane, Lena's husband who was part of the previous expedition into Area X and whose return raises more questions than answers.

Benedict Wong takes on the role of Lomax, a paramedic who joins the team on their perilous journey into the unknown territory of Area X.

Sonoya Mizuno plays Katie, a med student who becomes entangled in the mysteries of Area X and undergoes a transformative experience.

David Gyasi portrays Daniel, a physicist who is part of the team exploring the strange phenomena within Area X, facing both physical and metaphysical challenges.

John Schwab appears as the Paramedic, a member of the team who must confront the unknown dangers lurking within Area X while trying to survive.

Sammy Hayman takes on the role of Mayer, a member of the expedition team who faces the surreal and terrifying transformations happening within Area X.

Josh Danford portrays Shelley, a member of the team who encounters the inexplicable phenomena of Area X, adding to the sense of fear and uncertainty.