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Annihilation

Annihilation Cast

19 cast members · 12 with popularity data
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Most Popular Annihilation Cast Members

Natalie Portman is currently the most popular Annihilation cast member online with a Attention Score of 7.5. 3 of 19 cast members rank in the top 1,000 actors online today. Updated July 28, 2026.

1
Natalie Portman
Lena
7.5
#328 overall
2
Sonoya Mizuno
Humanoid / Katie (Med Student)
5.5
#623 overall
3
Oscar Isaac
Kane
4.7
#830 overall
4
Jennifer Jason Leigh
Dr Ventress
3.4
#1,429 overall
5
Tessa Thompson
Josie Radek
2.8
#1,923 overall
6
Benedict Wong
Lomax
2.6
#2,191 overall
7
Cosmo Jarvis
Special Ops Soldier (uncredited)
2.0
#3,012 overall
8
Gina Rodriguez
Anya Thorensen
1.1
#5,868 overall
9
Tuva Novotny
Cass Sheppard
0.8
#7,486 overall
10
David Gyasi
Daniel
0.8
#8,206 overall
11
Kola Bokinni
Peyton (uncredited)
0.6
#9,666 overall
12
John Schwab
Paramedic
0.1
#31,366 overall
13
Sammy Hayman
Mayer
—
14
Josh Danford
Shelley
—
15
Kristen McGarrity
Lena Double
—
16
Kumud Pant
Scientist
—
17
Honey Holmes
Scientist (uncredited)
—
18
Hiten Patel
Scientist (uncredited)
—
19
Matthew Simpson
Special Ops Soldier (uncredited)
—
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