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Annihilation

Annihilation Cast

19 cast members · 12 with popularity data
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Most Popular Annihilation Cast Members

Natalie Portman is currently the most popular Annihilation cast member online with a Attention Score of 8.5. 2 of 19 cast members rank in the top 1,000 actors online today. Updated August 17, 2026.

1
Natalie Portman
Lena
8.5
#275 overall
2
Oscar Isaac
Kane
5.1
#797 overall
3
Sonoya Mizuno
Humanoid / Katie (Med Student)
4.1
#1,092 overall
4
Jennifer Jason Leigh
Dr Ventress
3.8
#1,247 overall
5
Tessa Thompson
Josie Radek
2.9
#1,947 overall
6
Benedict Wong
Lomax
2.3
#2,580 overall
7
Cosmo Jarvis
Special Ops Soldier (uncredited)
1.6
#3,896 overall
8
Gina Rodriguez
Anya Thorensen
1.1
#6,069 overall
9
Tuva Novotny
Cass Sheppard
0.9
#7,026 overall
10
David Gyasi
Daniel
0.7
#8,540 overall
11
Kola Bokinni
Peyton (uncredited)
0.6
#9,451 overall
12
John Schwab
Paramedic
0.1
#35,094 overall
13
Sammy Hayman
Mayer
—
14
Josh Danford
Shelley
—
15
Kristen McGarrity
Lena Double
—
16
Kumud Pant
Scientist
—
17
Honey Holmes
Scientist (uncredited)
—
18
Hiten Patel
Scientist (uncredited)
—
19
Matthew Simpson
Special Ops Soldier (uncredited)
—
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