James Marsden provides the voice for Diggs, a brave but inexperienced dog who becomes a key player in the battle against Kitty Galore.
Nick Nolte voices Butch, a tough and experienced dog who guides Diggs through challenges during their mission.
Christina Applegate voices Catherine, a smart and resourceful agent in the ongoing conflict between cats and dogs.
Bette Midler lends her voice to Kitty Galore, the main antagonist who poses a significant threat to both cats and dogs.
Pascale Hutton plays Jackie, a skilled and fierce character in the animated world of the film.
Katt Williams voices Seamus, a character involved in the adventurous storyline as it unfolds.
Neil Patrick Harris provides the voice for Lou, a charismatic dog who plays an important role in the plot.
Sean Hayes voices Mr. Tinkles, a key character with a complex relationship with the protagonists.
Wallace Shawn lends his voice to Calico, a character that adds depth to the story.
Roger Moore provides the voice for Tab Lazenby, a stylish and suave character in the film.
Joe Pantoliano voices Peek, a comedic character that contributes to the humor of the storyline.
Michael Clarke Duncan plays Sam, a strong and dependable character in the animated film.
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