Scarlett Johansson plays Major Mira Killian, also known as Motoko Kusanagi, a cyber-enhanced human who leads an elite task force combating cyber-terrorism.
Takeshi Kitano portrays Chief Daisuke Aramaki, the leader of Section 9, the organization Major is a part of, known for his wisdom and strategic thinking.
Michael Pitt takes on the role of Kuze, also known as Hideo, a former member of Section 9 who has his own mysterious agenda.
Pilou Asbæk plays Batou, a loyal and strong-willed member of Section 9 who shares a close bond with Major and is known for his cybernetic eyes.
Chin Han portrays Togusa, a skilled detective in Section 9 who relies more on his human abilities than cybernetic enhancements.
Juliette Binoche plays Dr. Ouélet, a scientist who played a key role in creating Major's cybernetic body and is conflicted about her involvement in the project.
Peter Ferdinando portrays Cutter, a manipulative and ambitious businessman who is involved in shady dealings related to cybernetic technology.
Rila Fukushima plays the Red Robed Geisha, a mysterious and lethal figure who appears in Major's investigations, raising questions about her true identity.
Daniel Henshall plays Skinny Man, a dangerous criminal involved in illegal activities in the cyber-enhanced world of Ghost in the Shell.
Yutaka Izumihara portrays Saito, a skilled sniper and member of Section 9 who provides valuable support to Major and the team.
Anamaria Marinca plays Dr. Dahlin, a scientist involved in cybernetic research who becomes entangled in the moral dilemmas surrounding artificial intelligence and human identity.
Kaori Momoi portrays Hairi, a loyal assistant to Chief Aramaki who provides support and insights to the team at Section 9.
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