Luke Wilson plays the character Henry Poole.
George Lopez portrays the character Father Salizar.
Radha Mitchell takes on the role of Dawn Stupek.
Morgan Lily embodies the character Millie Stupek.
Adriana Barraza portrays the character Esperanza.
Cheryl Hines plays the character Meg.
Earl Carroll takes on the role of Mr. Lawrence.
Noah Dahl portrays the character Young Henry Poole.
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