Sandra Bullock plays Agnes von Kurowsky, a complex character who is a World War I nurse that becomes romantically involved with Ernest Hemingway.
Chris O'Donnell portrays Ernest 'Ernie' Hemingway, a young American ambulance driver who falls in love with Agnes von Kurowsky amidst the chaos of war.
Mackenzie Astin takes on the role of Henry Villard, a friend of Hemingway and fellow ambulance driver.
Margot Steinberg plays Mabel 'Rosie' Rose, a character involved in the lives of Agnes and Hemingway.
Alan Bennett portrays the character of Porter in the film.
Ingrid Lacey plays Elsie 'Mac' MacDonald, a nurse who works alongside Agnes von Kurowsky.
George Rossi plays the Triage Medic, a vital character in the medical assistance provided during the war.
Carlo Croccolo portrays the Town Mayor in the movie.
Laura Nardi plays the role of Teresa in the film.
Tara Hugo takes on the character of Katherine 'Gumshoe' De Long in the movie.
Diane Witter portrays the character of Adele Brown in In Love and War.
Allegra Di Carpegna plays Loretta Cavanaugh, a character entwined in the storyline of the film.
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