Woody Harrelson plays Roy Munson, a former bowling star whose life takes a turn for the worse.
Randy Quaid portrays Ishmael Boorg, a naïve and gifted bowler who becomes Roy's unlikely partner.
Vanessa Angel appears as Claudia, the love interest who gets involved with Roy Munson.
Bill Murray plays Ernie McCracken, a flamboyant and arrogant professional bowler.
Chris Elliott acts as The Gambler, a character who interacts with Roy and Ishmael during their journey.
William Jordan portrays Mr. Boorg, Ishmael's strict and controlling father.
Nancy Frey-Jarecki plays Sarah Boorg, Ishmael's supportive and caring mother.
Richard Tyson appears as the Owner Of Stiffy's, a bowling alley where significant events unfold.
Lin Shaye plays the Landlady, a character who provides a place for Roy and Ishmael.
Zen Gesner portrays Thomas, a minor character in the film.
Prudence Wright Holmes plays Mrs. Boorg, another member of Ishmael's family.
Rob Moran appears as Stanley Osmanski, a character involved in the larger bowling community.
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