Cast of Memento

Guy Pearce plays Leonard Shelby, a man suffering from short-term memory loss who is trying to solve the mystery of his wife's murder.

Carrie-Anne Moss portrays Natalie, a woman who becomes involved with Leonard and plays a significant role in his life.

Joe Pantoliano plays John Edward 'Teddy' Gammell, a key figure in Leonard's quest who claims to help him find the truth.

Mark Boone Junior takes on the role of Burt, a character who interacts with the main cast in the storyline.

Russ Fega plays the Waiter, a minor character in the film who adds to the atmosphere of the scenes.

Jorja Fox portrays Catherine Shelby, Leonard's wife whose murder becomes the central mystery.

Stephen Tobolowsky plays Samuel R. 'Sammy' Jankis, a character whose story provides context to Leonard's condition.

Harriet Sansom Harris takes on the role of Mrs. Jankis, who is related to Sammy and linked to the themes of the film.

Thomas Lennon portrays the Doctor, a character that interacts with Leonard at different points.

Callum Keith Rennie plays Dodd, a character who has a complicated interaction with Leonard and others.

Kimberly Campbell portrays the Blonde, a character who is part of the film's intricate narrative.

Marianne Muellerleile plays Emma, contributing to the film's plot and Leonard's journey.