The Astronaut's Wife Cast

Johnny Depp plays Commander Spencer Armacost, an astronaut who experiences a life-altering event during a space mission.

Charlize Theron portrays Jillian Armacost, the wife of Commander Armacost, who struggles with the changes in her husband after his return from space.

Joe Morton plays Sherman Reese, a NASA official who is involved in the investigation of the astronaut's mysterious transformation.

Clea DuVall plays Nan, a friend of Jillian Armacost who becomes concerned about the troubling changes in her life.

Nick Cassavetes portrays Captain Alex Streck, a fellow astronaut and colleague of Spencer.

Donna Murphy plays Natalie Streck, who is connected to the personal and emotional aspects of the astronauts' lives.

Gary Grubbs portrays the NASA Director, who oversees the operations and management of the space mission.

Blair Brown plays Shelly McLaren, who interacts with the main characters throughout the storyline.

Tom Noonan portrays Jackson McLaren, contributing to the environment surrounding the astronauts' experiences.

Tom O'Brien plays Allen Dodge, a character involved in the mission's narrative.

Lucy Lin portrays Shelly Carter, a supporting character who adds depth to the story.

Michael Crider plays Pat Elliott, a member of the cast depicted in various interactions.